Mandibular ghost cell odontogenic carcinoma: a case report and review of literature

Ghost cell odontogenic carcinoma (GCOC) is a rare malignant odontogenic tumor, Only 37 cases of GCOC have been reported in the English-language literature to date. This case presents an additional case, a 47-yearold Chinese man presented with a slow-growing mandibular lesion with history of ameloblastoma. The panoramic radiograph shows an ill-defined mixed radiolucency with radiopacity in the mandible. The histological examination confirms the diagnoses as a GCOC. Immunohistochemical examination was performed to detect Ki-67 and MMP-9 which are considered as predictive factors for cell proliferation and tumor invasion. This case was managed by wide surgical resection of tumor and reconstruction of the defect by free vascularized fibular flap. Six months followup period shows no signs of recurrence.